TNF and Brain Dysfunction
TNF is an immune signaling molecule that initiates and amplifies the inflammatory response in a variety of organ systems. In addition, TNF serves a variety of functions related to the immune modulation of neuronal and brain function. Increasing evidence suggests that excess TNF may be associated with brain dysfunction. Excess TNF may exert its deleterious effects via a variety of mechanisms related to modulation of synaptic transmission and synaptic scaling. Clinical observations by INR physicians over a period of more than a decade have contributed to the understanding of the role of TNF-mediated pathophysiology in a variety of neuroinflammatory disorders.
Dr. Tobinick's contributions to the medical literature include co-authorship of a medical textbook and more than 20 scientific articles that have published in peer-reviewed medical and scientific journals. These articles include recent reviews in the journals Expert Review of Neurotherapeutics, CNS Drugs, and Drug Discovery Today, as well as published articles in BMC Neurology, Current Alzheimer Research, and the Journal of Neuroinflammation.
When reporting their scientific results, scientists will discuss and refer to previous publications in their articles. These citations to the scientific literature are an integral part of the scientific process. There have been hundreds of scientific citations to Dr. Tobinick's publications, including in the journals Brain Research, Molecular Pain, Nature Clinical Practice Neurology, Neurobiology of Aging, Neuroscience, Pharmacology and Therapeutics, Spine and F1000 Biology.